| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 16/09/25 18:45 | Athletic Bilbao | FC Arsenal | --- |
| 16/09/25 18:45 | PSV Eindhoven | Royale Union Saint-Gilloise | --- |
| 16/09/25 21:00 | Tottenham Hotspur | Villarreal CF | --- |
| 16/09/25 21:00 | Benfica Lisbonne | Qarabag | --- |
| 16/09/25 21:00 | Juventus Turin | Borussia Dortmund | --- |
| 16/09/25 21:00 | Real Madrid | Olympique de Marseille | --- |
| 17/09/25 18:45 | Olympiakos | Pafos FC | --- |
| 17/09/25 18:45 | Slavia Prague | FK Bodö/Glimt | --- |
| 17/09/25 21:00 | Paris Saint-Germain | Atalanta Bergamo | --- |
| 17/09/25 21:00 | FC Liverpool | Atletico Madrid | --- |
| 17/09/25 21:00 | Ajax Amsterdam | Inter Milan | --- |
| 17/09/25 21:00 | Bayern Munich | FC Chelsea | --- |
| 18/09/25 18:45 | FC Bruges | AS Monaco | --- |
| 18/09/25 18:45 | FC Copenhague | Bayer 04 Leverkusen | --- |
| 18/09/25 21:00 | Sporting Lisbonne | Qairat Almaty | --- |
| 18/09/25 21:00 | Eintracht Frankfurt | Galatasaray Istanbul | --- |
| 18/09/25 21:00 | Manchester City | SSC Naples | --- |
| 18/09/25 21:00 | Newcastle United | FC Barcelone | --- |